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Trends Plant Sci. 2002 Oct;7(10):435-40.

Homologous recombination: ends as the means.

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Keck Graduate Institute, 535 Watson Drive, Claremont, CA 91711, USA.


Broken chromosomal ends in somatic cells of higher plants frequently heal by the ligation of DNA ends to unrelated sequences or to sequences with micro-homologies. This pathway of DNA-strand-break repair is the bane of gene-targeting attempts in plants. However, there is a second somatic pathway of chromosome repair, which is driven by DNA-sequence homology. Observations from yeast, fly and plants of homologous-recombination mechanisms point towards new strategies of gene targeting in plants.

[Indexed for MEDLINE]

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