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Trends Plant Sci. 2002 Oct;7(10):435-40.

Homologous recombination: ends as the means.

Author information

1
Keck Graduate Institute, 535 Watson Drive, Claremont, CA 91711, USA. animesh_ray@kgi.edu

Abstract

Broken chromosomal ends in somatic cells of higher plants frequently heal by the ligation of DNA ends to unrelated sequences or to sequences with micro-homologies. This pathway of DNA-strand-break repair is the bane of gene-targeting attempts in plants. However, there is a second somatic pathway of chromosome repair, which is driven by DNA-sequence homology. Observations from yeast, fly and plants of homologous-recombination mechanisms point towards new strategies of gene targeting in plants.

PMID:
12399177
[Indexed for MEDLINE]

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