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Cancer Cell. 2002 Oct;2(4):257-65.

Telomerase: a target for cancer therapeutics.

Author information

1
The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75309, USA. jerry.shay@utsouthwestern.edu

Abstract

The continuous growth of advanced malignancies almost universally correlates with the reactivation of telomerase. While there is still a great deal of basic and applied research to be done, telomerase remains a very attractive novel target for cancer therapeutics. In this review, we will discuss the challenges and the pros and cons of the most promising antitelomerase approaches currently being investigated.

PMID:
12398889
[Indexed for MEDLINE]
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