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J Nat Prod. 2002 Oct;65(10):1447-51.

Tupuseleiamides and basiliskamides, new acyldipeptides and antifungal polyketides produced in culture by a Bacillus laterosporus isolate obtained from a tropical marine habitat.

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Departments of Chemistry and Oceanography-Earth and Ocean Sciences, University of British Columbia, 2036 Main Mall, Vancouver, Canada.


Laboratory cultures of PNG 276, a Bacillus laterosporus isolate obtained from coastal waters off Papua New Guinea, have been shown to produce the novel metabolites basiliskamide A (1), basiliskamide B (2), tupuseleiamide A (3), and tupusleiamide B (4). The structures of 1 to 4 were elucidated by analysis of spectroscopic data and chemical degradation. Basiliskamides A (1) and B (2) show potent in vitro anti-Candida activity.

[Indexed for MEDLINE]

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