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Exerc Sport Sci Rev. 2002 Oct;30(4):184-90.

Human performance: a role for the ACE genotype?

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Department of Cardiovascular Genetics, Rayne Institute, University College London, UK.


The I allele of the angiotensin I-converting enzyme (ACE) gene is associated with lower ACE activity and endurance performance; an excess occurs in elite distance runners, rowers, and mountaineers, perhaps secondary to enhanced muscle efficiency. Conversely, the D allele is associated with training-related strength gain and elite power-oriented performance secondary to increased ACE and angiotensin II, a growth factor.

[Indexed for MEDLINE]

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