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Psychopharmacol Bull. 2001 Summer;35(3):135-49.

Premenstrual exacerbations of mood disorders.

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Department of Psychiatry, East Tennessee State University, Quillen College of Medicine, Box 70567, Johnson City, TN 37614, USA.


Premenstrual exacerbation of mood disorders has received little attention, despite the recent interest in premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS). Differentiating between PMDD/PMS and other disorders, which worsen premenstrually, is a poorly understood diagnostic challenge. Controversy also focuses on a possible coexistence of PMDD and other mood disorders. This review discusses the differences between mood-disorder exacerbations and premenstrual disorders, evidence for premenstrual magnification of mood disorders, and possible mechanisms for these variations as well as clinical implications.

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