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DNA Cell Biol. 2002 Sep;21(9):659-64.

Cytotoxic T-lymphocyte escape monitoring in simian immunodeficiency virus vaccine challenge studies.

Author information

1
University of Wisconsin at Madison, Department of Pathology, Madison, Wisconsin 53709, USA. doconnor@primate.wisc.edu

Abstract

Several vaccine studies have ameliorated disease progression in simian-human immunodeficiency virus (SHIV) infections. The successes of these vaccines have been largely attributed to protective effects of cytotoxic T-lymphocyte (CTL) responses, although the precise correlates of immune protection remain poorly defined. It is now well established that vigorous CTL and antibody responses can rapidly select for viral escape variants after HIV and SIV infection. Here we suggest that viral variation analyses should be performed on viruses derived from vaccinated, SIV-, or SHIV-challenged animals as a routine component of vaccine evaluation to determine the contribution of immune responses to the success (or failure) of the vaccine regimen. To illustrate the importance of escape analysis, we show that rapid emergence of escape variants postchallenge contributed to the failure of a DNA prime/MVA boost vaccine regimen encoding SIV Tat.

PMID:
12396608
DOI:
10.1089/104454902760330192
[Indexed for MEDLINE]

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