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Hum Pathol. 2002 Oct;33(10):1047-51.

Co-occurrence of neuroblastoma and nephroblastoma in an infant with Fanconi's anemia.

Author information

1
Division of Hematology/Oncology, University Children's Hospital Basel, Basel, Switzerland.

Abstract

We report the clinical, histologic, and genetic findings of concurrent neuroblastoma and nephroblastoma in an infant with Fanconi's anemia (FA). Both tumors had characteristic chromosomal aberrations. In particular, the neuroblastoma showed a gain of chromosome 17q, considered an important factor for prognosis. But untypical genetic changes were also seen suggesting that FA as a chromosomal instability syndrome causes new and untypical chromosomal variations in different tumors. The present case is unique because the simultaneous occurrence of a neuroblastoma and nephroblastoma with FA has not yet been described.

PMID:
12395380
[Indexed for MEDLINE]

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