Format

Send to

Choose Destination
Mol Neurobiol. 2002 Aug;26(1):45-55.

Neurobiology of glaucomatous optic neuropathy: diverse cellular events in neurodegeneration and neuroprotection.

Author information

1
Pharmacia Corporation, St Louis, MO 63138, USA. martin.b.wax@pharmacia.com

Abstract

Although glaucomatous optic nerve degeneration is a leading cause of worldwide blindness, neither the precise cellular mechanisms underlying neurodegeneration in glaucoma, nor effective strategies for neuroprotection are yet clear. This review focuses on diverse cellular events associated with glaucomatous neurodegeneration whose balance is critical for determination of ultimate cell fate. An improved understanding of the site of primary injury to optic nerve, the mediator pathways of apoptotic cell death and intrinsic protection mechanisms in retinal ganglion cells, the role of glial activation on the survival and death of retinal ganglion cell bodies and their axons, and the protective and destructive consequences of immune system involvement can facilitate development of effective neuroprotective strategies in glaucoma.

PMID:
12392055
DOI:
10.1385/MN:26:1:045
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center