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Expert Opin Ther Targets. 2002 Oct;6(5):555-61.

The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes.

Author information

1
Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University, Israel.

Abstract

Glycogen synthase kinase-3 (GSK-3) is a ubiquitous cytosolic serine/threonine protein kinase that has been implicated in multiple receptor-mediated intracellular processes. Its unique feature, which distinguishes it from other protein kinases, is that it is constitutively active in resting conditions and acts as a suppressor of signalling pathways. The fact that the function of two key targets of insulin action, glycogen synthase and insulin receptor substrate-1, are suppressed by GSK-3, as well as the fact that GSK-3 activity is higher in diabetic tissues, makes it a promising drug discovery target for insulin resistance and Type 2 diabetes. Thus, the development of GSK-3 inhibitors has received attention as an attempt to control both the spread of the disease and its severity.

PMID:
12387679
DOI:
10.1517/14728222.6.5.555
[Indexed for MEDLINE]

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