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Indian J Gastroenterol. 2002 Jul-Aug;21(4):153-4.

Phototherapy induces oxidative stress in premature neonates.

Author information

1
Department of Pediatrics, Pt. Bhagwat Dayal Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana. g_gathwala@hotmail.com

Abstract

BACKGROUND:

Phototherapy is a widely used treatment modality for unconjugated hyperbilirubinemia in newborn infants. We investigated whether phototherapy leads to oxidative stress in preterm newborns.

METHODS:

Thiobarbituric acid reactive substances (TBRS) were measured in the blood of 30 icteric preterm newborn infants, before and after 96 hours of continuous blue-light phototherapy. The mean (SD) gestational age was 32.3 (1.8) weeks and birth weight was 1606 (288) grams. The mean age of onset of jaundice was 44 (21.4) hours.

RESULTS:

The maximum total serum bilirubin was 14.6 (1.5) mg/dL and that after phototherapy was 8.6 (0.8) mg/dL. TBRS levels after phototherapy were significantly higher than those before phototherapy (11.4 [2.9] vs. 6.9 [2.2] nmol/L; [p<0.001]).

CONCLUSION:

Blue-light phototherapy induces an oxidative stress in preterm neonates.

PMID:
12385544
[Indexed for MEDLINE]

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