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J Cell Physiol. 2002 Dec;193(3):287-92.

Regulation of life and death by the zinc finger transcription factor Egr-1.

Author information

1
Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Homburg, Germany. bcgthi@uniklinik-saarland.de

Abstract

The biosynthesis of the zinc finger transcription factor Egr-1 is stimulated by many extracellular signaling molecules including hormones, neurotransmitters, growth and differentiation factors, and cytotoxic metabolites. The 5'-flanking region of the Egr-1 gene contains genetic elements that are essential in connecting stimulation of the cells with enhanced transcription of the Egr-1 gene, and subsequently, transcription of Egr-1-responsive genes. Thus, Egr-1 links cellular signaling cascades with changes in the gene expression pattern. Many biological functions have been attributed to Egr-1. Here, we discuss evidence for Egr-1 control of cellular proliferation and programmed cell death.

PMID:
12384981
DOI:
10.1002/jcp.10178
[Indexed for MEDLINE]

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