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Eur J Intern Med. 2002 Oct;13(7):458.

Severe Churg-Strauss syndrome with mediastinal lymphadenopathy treated with interferon therapy.

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Service des Maladies Infectieuses et Tropicales, Clinique Médicale A, Fédération des Services de Médecine Interne, Hôpital Civil, 1 place de l'Hôpital, B.P. 426, 67091 Cedex, Strasbourg, France


We report a case of severe Churg-Strauss syndrome (CSS) with mediastinal eosinophilic lymphadenopathy, with relapse after standard therapy with steroids and cyclophosphamide, subsequently treated with interferon (IFN) alpha 2b. Our report shows that mediastinal lymph nodes mimicking lymphoma may be one of the clinical manifestations of CSS. We also show that patients with CSS who are resistant to first-line therapy and for whom hypereosinophilia is thought to play an important role may benefit from treatment with IFN.

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