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Curr Opin Cell Biol. 2002 Aug;14(4):454-62.

Insights from yeast endosomes.

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1
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. hp@mrc-lmb.cam.ac.uk

Abstract

The endosomal system of yeast is simpler than that of animal cells, but as it is mapped more similarities are emerging. A key role for ubiquitin in sorting proteins to and into multivesicular bodies has been demonstrated. The finding that Phox homology domains recognise phosphatidylinositol 3-phosphate explains how sorting nexins are recruited to endosomes, where they mediate the retrieval of membrane proteins from the endocytic pathway.

PMID:
12383796
[Indexed for MEDLINE]
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