Hepatitis C: molecular virology and antiviral targets

Trends Mol Med. 2002 Oct;8(10):476-82. doi: 10.1016/s1471-4914(02)02395-x.

Abstract

Chronic hepatitis C is a leading cause of liver cirrhosis and hepatocellular carcinoma worldwide. Although current treatment options are limited, progress in understanding the molecular virology of hepatitis C has led to the identification of novel antiviral targets. Moreover, in vitro and in vivo model systems have been developed that allow systematic evaluation of new therapeutic strategies. This review details current concepts in molecular virology and emerging therapies for hepatitis C.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antiviral Agents / therapeutic use*
  • Genes, Viral
  • Hepacivirus / genetics*
  • Hepacivirus / metabolism
  • Hepacivirus / ultrastructure
  • Hepatitis C / drug therapy
  • Hepatitis C / metabolism
  • Hepatitis C / therapy*
  • Hepatitis C / virology*
  • Humans
  • Models, Molecular
  • Protein Processing, Post-Translational
  • Protein Structure, Quaternary
  • Viral Structural Proteins / chemistry
  • Viral Structural Proteins / metabolism

Substances

  • Antiviral Agents
  • Viral Structural Proteins