Synthesis and DNA cross-linking of a phototriggered FR900482 mitosene progenitor

Org Lett. 2002 Oct 17;4(21):3711-4. doi: 10.1021/ol0266774.

Abstract

[reaction: see text] The synthesis and biochemical reactivity of the first photoactivated mitosene-based DNA interstrand cross-linking agent is described.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Autoradiography
  • Base Sequence
  • DNA / chemistry*
  • Mitomycins / chemistry*
  • Oxazines / chemistry*
  • Photochemistry

Substances

  • Mitomycins
  • Oxazines
  • FR 900482
  • mitosene
  • DNA