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Am J Hypertens. 2002 Oct;15(10 Pt 1):903-6.

Impaired stress-induced pressure natriuresis increases cardiovascularload in African American youths.

Author information

1
Georgia Prevention Institute, Augusta, USA. gharshfi@mail.mcg.edu

Abstract

BACKGROUND:

We hypothesized that impaired stress-induced pressure natriuresis increases blood pressure (BP) load.

METHODS:

The 118 African American youths were brought into similar levels of sodium balance. The protocol consisted of a 2-h baseline period, a 1-h stress period (competitive video games), and a 2-h recovery period.

RESULTS:

Normal pressure natriuresis (n = 80) resulted from a resistance-mediated (r = 0.23; P <.03) increase in BP (P <.001). In contrast, impaired pressure natriuresis (n = 38), leading to an extended period of elevated BP (P <.05), resulted from a volume-mediated (r = 0.55; P <.002) increase in BP (P <.001).

CONCLUSIONS:

Impaired stress-induced pressure natriuresis may contribute to the development of essential hypertension, particularly in African Americans.

PMID:
12372678
[Indexed for MEDLINE]
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