Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2002 Nov 4;12(21):3141-3.

Synthesis and structure--activity relationship of novel aminotetralin derivatives with high micro selective opioid affinity.

Author information

1
Shire Biochem, 275 Armand-Frappier Blvd., Laval, H7V 4A7, Québec, Canada. croy@ca.shire.com

Abstract

Several novel racemic aminotetralin derivatives have been prepared using a stereoselective aziridine ring opening reactions and were evaluated for their micro-opioid receptor binding affinity. Selectivity index towards other opioid receptors and antinociceptive activity in mice have been evaluated for the most potent derivatives.

PMID:
12372519
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center