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Fertil Steril. 2002 Oct;78(4):733-9.

Usefulness of CA19-9 versus CA125 for the diagnosis of endometriosis.

Author information

1
Department of Comprehensive Reproductive Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. t.harada.gyne@tmd.ac.jp

Abstract

OBJECTIVE:

To investigate the clinical value of the serum CA19-9 level in comparison with the serum CA125 level for diagnosing and determining the severity of endometriosis.

DESIGN:

Retrospective study.

SETTING:

Department of Comprehensive Reproductive Medicine in a university hospital.

PATIENT(S):

One hundred one women with endometriosis and 22 without endometriosis participated in this study.

INTERVENTION(S):

Blood samples were collected before the operation (laparoscopy, oophrectomy, cystectomy, and/or hysterectomy), and tissue samples of ovarian chocolate cysts were collected during the operation.

MAIN OUTCOME MEASURE(S):

The serum CA19-9 and CA125 levels and the localization of these antigens in ovarian chocolate cysts.

RESULT(S):

The mean serum CA19-9 levels in patients at all stages of endometriosis were significantly higher than those in patients without endometriosis, and serum CA19-9 levels significantly correlated with the Revised American Fertility Society classification scores. Intense staining of CA19-9 was observed in 15 of the 20 samples of ovarian chocolate cysts.

CONCLUSION(S):

CA19-9 is a useful marker for determining the severity of endometriosis.

PMID:
12372448
[Indexed for MEDLINE]

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