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Histol Histopathol. 2002 Oct;17(4):1213-26. doi: 10.14670/HH-17.1213.

CD26: an expanding role in immune regulation and cancer.

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Department of Lymphoma/Myeloma, MD Anderson Cancer Center, Box 429, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.


In this review, we highlight major aspects of the biology of CD26, a dipeptidyl peptidase IV (DPPIV)-containing surface glycoprotein with multiple functions. In particular, we discuss findings demonstrating that CD26/DPPIV has an essential role in immune regulation as a T cell activation molecule and a regulator of chemokine function. We also review recent studies that identify key cellular molecules that physically associate with CD26 and the potential consequences of their interaction, including those with clinically-related implications. Furthermore, we present work suggesting a role for CD26 in the pathogenesis and behavior of selected human cancers, both solid tumors and hematological malignancies. We present recent studies that investigate the potential role of CD26 as a molecular target for novel treatment modalities for T cell lymphoid malignancies and possibly other hematological malignancies, with work involving the use of anti-CD26 monoclonal antibody, CD26-transfected cells as well as soluble CD26 molecules.

[Indexed for MEDLINE]

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