Structure-activity relationship, conformation and pharmacology studies of morphiceptin analogues--selective mu-opioid receptor ligands

Mini Rev Med Chem. 2002 Dec;2(6):565-72. doi: 10.2174/1389557023405567.

Abstract

Morphiceptin (Tyr-Pro-Phe-Pro-NH(2)) is one of the most selective agonists for the mu-opioid receptor. In this review structure-activity relationships of morphiceptin analogues and studies resulting in defining low energy conformations are discussed. Finally, new developments in the control of tumour growth and cell proliferation by morphiceptin analogues are surveyed, which open future perspectives in the diagnosis and treatment of various cancers.

Publication types

  • Review

MeSH terms

  • Analgesics, Opioid / chemistry
  • Analgesics, Opioid / pharmacology*
  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Division / drug effects
  • Cyclization
  • Endorphins / chemistry
  • Endorphins / pharmacology*
  • Humans
  • Ligands
  • Protein Conformation
  • Receptors, Opioid, mu / agonists*
  • Receptors, sigma / antagonists & inhibitors
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • Analgesics, Opioid
  • Antineoplastic Agents
  • Endorphins
  • Ligands
  • Receptors, Opioid, mu
  • Receptors, sigma
  • morphiceptin