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J Perinatol. 2002 Oct-Nov;22(7):516-22.

Changes in early-onset group B beta hemolytic streptococcus disease with changing recommendations for prophylaxis.

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1
Department of Pediatrics, Division of Neonatology, Golisano Children's Hospital at Strong, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

Abstract

OBJECTIVE:

To determine the incidence of early-onset group B beta hemolytic streptococcal (EOGBS) infection and the association between changes in the incidence and intrapartum antibiotic prophylaxis (IAP).

STUDY DESIGN:

A retrospective population survey of infants with GBS at < 7 days of age with a nested case-control study of non-GBS infants over the same time period, January 1985 to December 1998. The incidence of GBS and maternal antibiotic treatment during labor was analyzed as a function of time period: prior to publication of guidelines for prevention of EOGBS (1985-1992), following AAP/ACOG guidelines (1993-1995), and following CDC consensus guidelines (1996-1998).

RESULTS:

Fifty-six cases of EOGBS infection occurred among 53,088 live births. The incidence declined from 1.5/1000 before any guidelines to 0.67/1000 after AAP/ACOG guidelines (p = 0.004), and continued to decline after the CDC consensus statement (0.28/1000) (p = 0.38). IAP remained stable (33% of at risk mothers) until after introduction of the CDC consensus guidelines (59%, p = 0.02).

CONCLUSION:

IAP did not fully explain the decline in EOGBS incidence in our center.

PMID:
12368965
DOI:
10.1038/sj.jp.7210798
[Indexed for MEDLINE]
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