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Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13477-80. Epub 2002 Oct 4.

Structural analysis of the RSC chromatin-remodeling complex.

Author information

1
Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. asturias@scripps.edu

Abstract

Electron microscopy of the RSC chromatin-remodeling complex reveals a ring of protein densities around a central cavity. The size and shape of the cavity correspond closely to those of a nucleosome. Results of nuclease protection analysis are consistent with nucleosome binding in the cavity. Such binding could explain the ability of RSC to expose nucleosomal DNA in the presence of ATP without loss of associated histones.

PMID:
12368485
PMCID:
PMC129698
DOI:
10.1073/pnas.162504299
[Indexed for MEDLINE]
Free PMC Article

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