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J Virol. 2002 Nov;76(21):11143-7.

Identification of the hepatitis C virus E2 glycoprotein binding site on the large extracellular loop of CD81.

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  • 1St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia.


The binding of hepatitis C virus glycoprotein E2 to the large extracellular loop (LEL) of CD81 has been shown to modulate human T-cell and NK cell activity in vitro. Using random mutagenesis of a chimera of maltose-binding protein and LEL residues 113 to 201, we have determined that the E2-binding site on CD81 comprises residues Ile(182), Phe(186), Asn(184), and Leu(162). These findings reveal an E2-binding surface of approximately 806 A(2) and potential target sites for the development of small-molecule inhibitors of E2 binding.

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