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Trends Biochem Sci. 2002 Oct;27(10):497-500.

BLUF: a novel FAD-binding domain involved in sensory transduction in microorganisms.

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Department of Molecular Biology, University of Wyoming, Laramie, WY 82071-3944, USA.


A novel FAD-binding domain, BLUF, exemplified by the N-terminus of the AppA protein from Rhodobacter sphaeroides, is present in various proteins, primarily from Bacteria. The BLUF domain is involved in sensing blue-light (and possibly redox) using FAD and is similar to the flavin-binding PAS domains and cryptochromes. The predicted secondary structure reveals that the BLUF domain is a novel FAD-binding fold.

[Indexed for MEDLINE]

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