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Trends Biochem Sci. 2002 Oct;27(10):495-7.

YTH: a new domain in nuclear proteins.

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  • 1Institute of Biochemistry, Friedrich-Alexander-University Erlangen-Nuremberg, Fahrstrasse 17, 91054, Erlangen, Germany.


A novel 100-150-residue domain has been identified in the human splicing factor YT521-B and its Drosophila and yeast homologues. Homology searches show that the domain is typical for the eukaryotes and is particularly abundant in plants. It is predicted to adopt a mixed alpha-helix-beta-sheet fold and to bind to RNA. We propose the name YTH (for YT521-B homology) for the domain.

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