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Trends Pharmacol Sci. 2002 Oct;23(10):482-6.

Statins as anti-inflammatory agents.

Author information

1
Novartis Pharma AG, Preclinical Research, Basel, Switzerland. gabriele.weitz@pharma.novartis.com

Abstract

The beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) in cardiovascular disease have generally been attributed to their cholesterol-lowering property. However, an increasing number of in vitro and in vivo studies indicate that statins have direct anti-inflammatory effects that are not mediated by their hypocholesterolemic activity. In this article, the HMG-CoA-reductase-dependent and -independent mechanisms by which statins might affect leukocyte adhesion and migration to sites of inflammation are reviewed and the implications for the design of new statin-derived drugs are discussed.

PMID:
12368073
DOI:
10.1016/s0165-6147(02)02077-1
[Indexed for MEDLINE]

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