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Curr Opin Neurobiol. 2002 Oct;12(5):516-22.

PTEN function in mammalian cell size regulation.

Author information

1
Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, 610 University Avenue, Toronto, Canada. sbackman@uhnres.utoronto.edu

Abstract

The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation.

PMID:
12367630
DOI:
10.1016/s0959-4388(02)00354-9
[Indexed for MEDLINE]

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