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Muscle Nerve. 2002 Oct;26(4):546-8.

Biopsy sampling requirements for the estimation of muscle capillarization.

Author information

1
Faculty of Physical Education and Recreation Studies, University of Manitoba, 207 Max Bell Centre, Winnipeg, Manitoba R3T 2N2, Canada. portermm@ms.umanitoba.ca

Abstract

The aim of this study was to determine the number of tibialis anterior biopsy samples and muscle fibers required to estimate the capillary supply of individual muscle fibers (C:F(i)). C:F(i) was calculated for 25 type 1 fibers in each of 8 images from 3 biopsies of 5 young healthy individuals. Sequential estimation analysis indicated that 50 fibers from one biopsy are sufficient to characterize the C:F(i) of the tibialis anterior for a group of subjects. Thus, when analyzing the capillarization of the tibialis anterior, the requirements of only one biopsy sample and 50 fibers means a great reduction in time for analysis and in the invasiveness of the procedure.

PMID:
12362422
DOI:
10.1002/mus.10221
[Indexed for MEDLINE]

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