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J Cutan Med Surg. 2003 Jan-Feb;7(1):1-6. Epub 2002 Oct 9.

Barrier and antibacterial properties of 2-octyl cyanoacrylate-derived wound treatment films.

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  • 1Department of Dermatology & Cutaneous Surgery, University of Miami School of Medicine, Miami, Florida 33136, USA.



Besides enhancing healing, an ideal dressing should prevent invasion of pathogens and control the number of bacteria already present in the wounds.


To evaluate the barrier and antimicrobial properties of a cyanoacrylate-based bandage (LAB) against Staphylococcus aureus or Pseudomonas aeruginosa on partial thickness wounds in swine.


Barrier study: Bacteria were inoculated over test materials (LAB, standard bandage, air-exposed) that were placed over wounds. The bacteria from wounds were quantitated at 24, 48, and 72 hours postinoculation. Antimicrobial study: Wounds inoculated with bacteria were covered with LAB, standard bandage, or hydrocolloid bandage or left air-exposed. The bacteria recovered from wounds were quantitated at 24 and 72 hours after treatment.


Barrier study: No bacteria were recovered from LAB-treated wounds. Antimicrobial study: LAB reduced the number of inoculated bacteria in comparison to all other groups.


LAB is effective in protecting wounds from external bacterial invasion and reducing bacterial contamination.

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