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J Cutan Med Surg. 2003 Jan-Feb;7(1):1-6. Epub 2002 Oct 9.

Barrier and antibacterial properties of 2-octyl cyanoacrylate-derived wound treatment films.

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  • 1Department of Dermatology & Cutaneous Surgery, University of Miami School of Medicine, Miami, Florida 33136, USA. pmertz@med.miami.edu

Abstract

BACKGROUND:

Besides enhancing healing, an ideal dressing should prevent invasion of pathogens and control the number of bacteria already present in the wounds.

OBJECTIVE:

To evaluate the barrier and antimicrobial properties of a cyanoacrylate-based bandage (LAB) against Staphylococcus aureus or Pseudomonas aeruginosa on partial thickness wounds in swine.

METHODS:

Barrier study: Bacteria were inoculated over test materials (LAB, standard bandage, air-exposed) that were placed over wounds. The bacteria from wounds were quantitated at 24, 48, and 72 hours postinoculation. Antimicrobial study: Wounds inoculated with bacteria were covered with LAB, standard bandage, or hydrocolloid bandage or left air-exposed. The bacteria recovered from wounds were quantitated at 24 and 72 hours after treatment.

RESULTS:

Barrier study: No bacteria were recovered from LAB-treated wounds. Antimicrobial study: LAB reduced the number of inoculated bacteria in comparison to all other groups.

CONCLUSION:

LAB is effective in protecting wounds from external bacterial invasion and reducing bacterial contamination.

[PubMed - indexed for MEDLINE]
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