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Microbes Infect. 2002 Sep;4(11):1169-75.

HIV and hepatitis delta virus: evolution takes different paths to relieve blocks in transcriptional elongation.

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  • 1Graduate School of Bioscience and Biotechnology, 4259 Nagatsuta, Yokohama 226-8503, Japan.


The elongation step of transcription by RNA polymerase II (RNAPII) is controlled both positively and negatively by over a dozen cellular proteins. Recent findings suggest that two distinct viruses, human immunodeficiency virus type 1 and hepatitis delta virus, encode proteins that facilitate viral replication and transcription by targeting the same cellular transcription elongation machinery.

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