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Hear Res. 2002 Oct;172(1-2):14-7.

CGRP- and cholinergic-containing fibers project to guinea pig outer hair cells.

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Department of Otolaryngology, University of Miami School of Medicine, 1600 NW 10th Avenue, RMSB 3160, Miami, FL 33136, USA.


MU33, an antibody to calcitonin gene-related peptide (CGRP), was used to investigate the magnitude of CGRP-containing nerve fiber endings, compared to acetylcholinesterase (AChE)-containing nerve fiber endings on outer hair cells (OHCs). Results showed that CGRP-containing nerve fiber immunoreactivity mimicked the AChE fiber OHC staining pattern across the cochlea suggesting that CGRP can function as both a medial efferent (contacting primarily OHCs) and as a lateral efferent (contacting primarily inner hair cell afferents) neurotransmitter.

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