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Nat Rev Cancer. 2002 Oct;2(10):777-85.

Deregulated homeobox gene expression in cancer: cause or consequence?

Author information

1
Centre for Advanced Biotechnology and Medicine, Departments of Medicine and Neuroscience, The Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, New Jersey 08854, USA. abate@cabm.rutgers.edu

Abstract

Homeobox genes comprise a large and essential family of developmental regulators that are vital for all aspects of growth and differentiation. Although many studies have reported their deregulated expression in cancer, few studies have established direct functional roles for homeobox genes in carcinogenesis. Nonetheless, most cases of deregulated homeobox gene expression in cancer conform to a simple rule: those that are normally expressed in undifferentiated cells are upregulated in cancer, whereas those that are normally expressed in differentiated tissues are downregulated in cancer.

PMID:
12360280
DOI:
10.1038/nrc907
[Indexed for MEDLINE]

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