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Nat Rev Cancer. 2002 Oct;2(10):764-76.

c-MYC: more than just a matter of life and death.

Author information

1
Molecular Medicine Research Centre, University of Warwick, Coventry CV4 7AL, UK. SPelengaris@bio.warwick.ac.uk

Abstract

Deregulated expression of c-MYC occurs in a broad range of human cancers and is often associated with poor prognosis, indicating a key role for this oncogene in tumour progression. However, as established human tumours often bear multiple genetic lesions, it is difficult to determine whether c-MYC is instrumental in the initiation/progression of the tumour, or indeed whether inactivating c-MYC would lead to tumour regression. Regulatable transgenic mouse models of oncogenesis have shed light on these issues and provide hope for effective cancer therapies.

PMID:
12360279
DOI:
10.1038/nrc904
[Indexed for MEDLINE]

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