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Nat Rev Cancer. 2002 Oct;2(10):740-9.

Transcription factors as targets for cancer therapy.

Author information

1
Laboratory of Molecular Cell Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. darnell@rockefeller.edu

Abstract

A limited list of transcription factors are overactive in most human cancer cells, which makes them targets for the development of anticancer drugs. That they are the most direct and hopeful targets for treating cancer is proposed, and this is supported by the fact that there are many more human oncogenes in signalling pathways than there are oncogenic transcription factors. But how could specific transcription-factor activity be inhibited?

PMID:
12360277
DOI:
10.1038/nrc906
[Indexed for MEDLINE]
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