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Nat Rev Immunol. 2002 Oct;2(10):797-804.

Unravelling the pathogenesis of myasthenia gravis.

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1
Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK. Angela.Vincent@imm.ox.ac.uk

Abstract

Myasthenia gravis is a relatively rare neurological disease that is associated with loss of the acetylcholine receptors that initiate muscle contraction. This results in muscle weakness, which can be life-threatening. The story of how both the physiological basis of the disease and the role of acetylcholine-receptor-specific antibodies were determined is a classic example of the application of basic science to clinical medicine, and it has provided a model for defining other antibody-mediated disorders of the peripheral and central nervous systems.

PMID:
12360217
DOI:
10.1038/nri916
[Indexed for MEDLINE]
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