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Nat Rev Immunol. 2002 Oct;2(10):748-59.

Emerging roles of PPARs in inflammation and immunity.

Author information

1
Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, Utah 84132-2501, USA. daynes.office@path.utah.edu

Abstract

Lipids and lipid metabolism have well-documented regulatory effects on inflammatory processes. Recent work has highlighted the role of the peroxisome proliferator-activated receptors (PPARs)--a subset of the nuclear-hormone-receptor superfamily that are activated by various lipid species--in regulating inflammatory responses. Here, we describe how the PPARs, through their interactions with transcription factors and other cell-signalling systems, have important regulatory roles in innate and adaptive immunity.

PMID:
12360213
DOI:
10.1038/nri912
[Indexed for MEDLINE]

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