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Nat Rev Mol Cell Biol. 2002 Oct;3(10):779-87.

How death shapes life during development.

Author information

  • 1Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA. baehreck@umbi.umd.edu

Abstract

The formation of an adult animal from a fertilized embryo involves the production and death of cells. Surprisingly, many cells are produced during development with an ultimate fate of death, and defects in programmed cell death can result in developmental abnormalities. Recent studies indicate that cells can die by many different mechanisms, and these differences have implications for proper animal development and disorders such as cancer and autoimmunity.

PMID:
12360194
DOI:
10.1038/nrm931
[PubMed - indexed for MEDLINE]
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