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Nat Rev Mol Cell Biol. 2002 Oct;3(10):767-78.

The many functions of SMC proteins in chromosome dynamics.

Author information

1
The Carl C. Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA. rolf.jessberger@mssm.edu

Abstract

Members of the structural maintenance of chromosomes (SMC) family share a characteristic design and configuration of protein domains that provides the molecular basis for the various functions of this family in chromosome dynamics. SMC proteins have a role in chromosome condensation, sister-chromatid cohesion, DNA repair and recombination, and gene dosage compensation, and they function in somatic and meiotic cells. As more is learned about how their unique design affects their function, a picture of a dynamic and varied protein family is emerging.

PMID:
12360193
DOI:
10.1038/nrm930
[Indexed for MEDLINE]

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