Format

Send to

Choose Destination
See comment in PubMed Commons below
Addiction. 2002 Oct;97(10):1241-9.

A systematic review on the efficacy of naltrexone maintenance treatment in opioid dependence.

Author information

1
Department of Epidemiology, ASL RM/E, Rome, Italy. setil@asplazio.it

Abstract

AIM:

To evaluate the efficacy of naltrexone maintenance treatment in preventing relapse in opioid addicts after detoxification.

DESIGN:

A systematic review according to the methodology developed by the Cochrane Collaboration based on either randomized controlled trials (RCTs) or controlled clinical trials (CCTs).

PARTICIPANTS:

Seven hundred and seven heroin dependent in- and out-patients, or former heroin addicts dependent on methadone and participating in a naltrexone treatment programme; 89% were male.

INTERVENTION:

Maintenance treatments on opiate dependent people after detoxification, comparing naltrexone with placebo, pharmacological or behavioural treatments.

MEASUREMENTS:

The outcomes considered were successfully completed treatment, opioid use under treatment (re)-incarcerations during the study period, mean duration of treatment.

FINDINGS:

The outcomes tended to be slightly although not significantly in favour of the naltrexone groups. Use of naltrexone in addition to behavioural treatment significantly decreased the probability of (re-)incarceration (OR=0.30; 95% CI 0.12, 0.76). The difficulties in producing a quantitative analysis were due mainly to the heterogeneity of the included studies.

CONCLUSIONS:

From the available clinical trials performed up to this time, there is insufficient evidence to justify the use of naltrexone in maintenance treatment of opioid addicts.

PMID:
12359026
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center