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Br J Haematol. 2002 Oct;119(1):122-4.

Mast cell infiltration correlates with poor prognosis in Hodgkin's lymphoma.

Author information

1
Department of Oncology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden. daniel.molin@onkologi.uu.se

Abstract

Hodgkin's lymphoma (HL) is characterized by a few Hodgkin, Reed-Sternberg cells (HRS) surrounded by benign cells. We recently reported that mast cells were the predominant CD30L-positive cells in HL tumours, and that they activate HRS in vitro through CD30L-CD30 interaction. Here, we investigated the clinical importance of mast cell infiltration in the tumours of 123 patients. Tumour specimens were stained with a mast-cell-specific antibody that detects tryptase. Mast cells were detected in virtually every case and increasing numbers of mast cells correlated to nodular sclerosis histology (P = 0.008). Patients with higher mast cell infiltration had a worse relapse-free survival (P = 0.01).

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