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Eur J Immunogenet. 2002 Oct;29(5):453-5.

Complete cDNA sequences of the HLA-DRB1*0402 and DRB1*11041 alleles.

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  • 1Anthony Nolan Research Institute and Department of Haematology, The Royal Free Hospital, London, UK.


Since the development of the polymerase chain reaction, most HLA class II allele sequencing has been exclusively focused on the highly polymorphic exon 2. We present here the full cDNA sequences of two HLA-DRB1 alleles, DRB1*0402 and DRB1*11041, both of which were previously only available as partial sequences. HLA-DRB1*11041 was found to be completely homologous to DRB1*11011 in exons 1, 3, 4, 5 and 6 and HLA-DRB1*0402 was found to be identical to DRB1*04011 in exons 1, 3, 4, 5 and 6.

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