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J Nerv Ment Dis. 2002 Sep;190(9):583-92.

Design and reporting modifications in industry-sponsored comparative psychopharmacology trials.

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Departments of Psychiatry and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, 7702 Dunmanway, Dundalk, MD 21222, USA.


This review of recently published pharmaceutical industry-sponsored comparative psychotropic drug trials aims to classify apparent design and reporting modifications that favor the sponsor's product. The modifications have been grouped into 13 discrete categories, and representative examples of each are presented. Strong circumstantial evidence suggests that marketing goals led to these adjustments. The consequences of marketing influences on comparative psychopharmacology trials are discussed in terms of conflicts of interest, the integrity of the scientific literature, and costs to consumers, as well as their impact on physician practice.

[Indexed for MEDLINE]

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