Format

Send to

Choose Destination
See comment in PubMed Commons below
Surg Oncol. 2002 Nov;11(3):123-35.

Hepatic artery chemotherapy for colorectal liver metastases: technical considerations and review of clinical trials.

Author information

  • 13302 Comprehensive Cancer Center, Division of Surgical Oncology, University of Michigan medical center, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA.

Abstract

Hepatic artery infusion (HAI) of chemotherapeutic agents for colorectal hepatic metastases is associated with significantly higher response rates compared to systemic chemotherapy. However, response rates have not consistently translated into improved survival. Several randomized trials have evaluated the implantable pump for treating unresectable colorectal hepatic metastases. Meta-analysis of these studies have demonstrated an improved survival advantage with pump therapy as well as improved quality of life. Recent studies of HAI of chemotherapy as adjuvant therapy following liver metastases resection have also demonstrated a potential survival advantage. Toxicities of HAI can be treatment limiting, but measures have emerged for overcoming these side effects. These randomized clinical trials have established HAI as a reasonable therapeutic option in patients with unresectable disease, and as adjuvant therapy in patients with resectable disease.

PMID:
12356508
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center