Format

Send to

Choose Destination
See comment in PubMed Commons below
Can J Psychiatry. 2002 Sep;47(7):666-70.

Proton magnetic resonance spectroscopy of the hippocampus and occipital white matter in PTSD: preliminary results.

Author information

1
PTSD Clinic, Veterans Administration Hospital, Departments of Psychiatry and Neurosciences, University of New Mexico, Albuquerque, New Mexico, USA. gerardo.villarreal@med.va.gov

Abstract

OBJECTIVE:

Previous proton magnetic resonance spectroscopy (1H-MRS) studies in posttraumatic stress disorder (PTSD) report decreased hippocampal N-acetylaspartate (NAA), an indicator of neuronal integrity. However, other areas of the brain need to be explored. The objective of this study was to investigate the specificity of hippocampal NAA concentration changes in PTSD by also examining a control region, the occipital white matter (OWM).

METHODS:

Eight patients with PTSD and 5 control subjects underwent single-voxel 1H-MRS of the hippocampi and bilateral OWM. Absolute neurometabolite concentrations were determined.

PRELIMINARY RESULTS:

Trends toward reduced left hippocampal NAA and creatine (Cre) were found in the PTSD group. PTSD subjects also had reduced bilateral OWM Cre.

CONCLUSIONS:

The preliminary results of our study in civilians with PTSD replicate previous MRS studies and are consistent with decreased hippocampal neuronal integrity without effects in the OWM. Replication of our findings is needed.

PMID:
12355679
DOI:
10.1177/070674370204700709
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center