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Immunity. 2002 Sep;17(3):363-73.

CD4+CD3- cells induce Peyer's patch development: role of alpha4beta1 integrin activation by CXCR5.

Author information

1
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland. dfinke@isrec.unil.ch

Abstract

CD4+CD3- cells are the predominant hematopoietic cells found in mouse fetal intestine. We prove their role as Peyer's patch (PP)-inducing cells by transfer into neonatal PP-deficient mice. To test the requirement of chemokines and adhesion molecules in induction of PP, we studied mice deficient in CXCR5 and/or alpha4beta1 integrin-mediated adhesion. CXCR5-/- mice have CD4+CD3- cells, which are inefficient in inducing PP formation. We show here that CXCR5/CXCL13 signaling activates alpha4beta1 integrin on CD4+CD3- cells. Blocking of beta1 integrin or VCAM-1, the ligand of alpha4beta1 integrin, inhibits PP formation. This study demonstrates the link between chemokine receptors and adhesion molecules that regulates stromal/hematopoietic cell interaction leading to PP formation.

PMID:
12354388
DOI:
10.1016/s1074-7613(02)00395-3
[Indexed for MEDLINE]
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