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Immunity. 2002 Sep;17(3):341-52.

Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses.

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1
Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA.

Abstract

Marginal zone (MZ) and B1 B lymphocytes participate jointly in the early immune response against T-independent (TI) particulate antigens. Here we show that blood-derived neutrophil granulocytes and CD11c(lo) immature dendritic cells (DC) are the primary cells that efficiently capture and transport particulate bacteria to the spleen. In a systemic infection, CD11c(lo) DC, but not neutrophils, provide critical survival signals, which can be inhibited by TACI-Fc, to antigen-specific MZ B cells and promote their differentiation into IgM-secreting plasmablasts. In a local TI response, peritoneal cavity macrophages provide similar support to B1 B-derived Ag-specific blasts. In the absence of soluble TACI ligands, Ag-activated MZ- and B1-derived blasts lack survival signals and undergo apoptosis, resulting in severely impaired antibody responses.

PMID:
12354386
[Indexed for MEDLINE]
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