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J Neurochem. 2002 Sep;82(6):1566-9.

Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth.

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1
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

Abstract

A protein fraction purified from bovine brain myelin, previously called arretin because of its ability to inhibit neurite outgrowth, has been identified as consisting predominantly of oligodendrocyte-myelin glycoprotein (OMgp). We show that it is a potent inhibitor of neurite outgrowth from rat cerebellar granule and hippocampal cells; from dorsal root ganglion explants in which growth cone collapse was observed; from rat retinal ganglion neurons; and from NG108 and PC12 cells. OMgp purified by a different procedure from both mouse and human myelin behaves identically in all bioassays tested.

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