Hydrolytically active tetranuclear nickel complexes with structural resemblance to the active site of urease

Håkan Carlsson; Matti Haukka; Ebbe Nordlander

doi:10.1021/ic025839p

Hydrolytically active tetranuclear nickel complexes with structural resemblance to the active site of urease

Inorg Chem. 2002 Oct 7;41(20):4981-3. doi: 10.1021/ic025839p.

Authors

Håkan Carlsson¹, Matti Haukka, Ebbe Nordlander

Affiliation

¹ Inorganic Chemistry, Center for Chemistry and Chemical Engineering, Lund University, Box 124, SE-221 00 Lund, Sweden.

PMID: 12354025
DOI: 10.1021/ic025839p

Abstract

Reaction of the new asymmetric ligand 2-(N-isopropyl-N-((1-methylimidazolyl)methyl)aminomethyl)-6-(N-carboxylmethyl-N-((1-methylimidazolyl)methyl) aminomethyl)-4-methylphenol (ICIMP) with nickel perchlorate and diphenylacetic acid leads to the formation of tetranuclear nickel complexes, whose crystal structures reveal that they consist of dimers of dimers in which each Ni(2) unit has a coordination environment that is similar to the active site of urease. One complex has been shown to coordinate urea and catalyze the hydrolysis of an organophosphate monoester.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacillus / enzymology*
Binding Sites
Catalysis
Crystallography, X-Ray
Imidazoles / chemistry*
Ligands
Models, Molecular
Molecular Conformation
Molecular Structure
Nickel / chemistry*
Organometallic Compounds / chemistry*
Urease / chemistry*
Urease / metabolism

Substances

2-(N-isopropyl-N-((1-methylimidazolyl)methyl)aminomethyl)-6-(N-carboxylmethyl-N-((1-methylimidazolyl)methyl)aminomethyl)-4-methylphenol
Imidazoles
Ligands
Organometallic Compounds
Nickel
Urease