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Acta Derm Venereol. 2002;82(3):174-8.

Treponema pallidum induces up-regulation of interstitial collagenase in human dermal fibroblasts.

Author information

1
Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea. kychung@yumc.yonsei.ac.kr

Abstract

In this study we investigated the capability of Treponema pallidum to stimulate human dermal fibroblasts to produce interstitial collagenase (MMP-1), which is needed to degrade type I collagen, the most abundant component of the human dermis. When T. pallidum was added to human dermal fibroblast culture, both the amount of secreted MMP-1 and its mRNA levels were increased. Our results show that T. pallidum can stimulate host human fibroblasts to increase the synthesis of MMP-1, which may act as a virulence factor of the organism.

PMID:
12353706
DOI:
10.1080/00015550260132442
[Indexed for MEDLINE]
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