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Transplantation. 2002 Aug 27;74(4):576-8.

The association of viral infection and chronic allograft nephropathy with graft dysfunction after renal transplantation.

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1
Department of Infection, Guys' and St. Thomas' Hospital Trust, London, UK. william.tong@gstt.sthames.nhs.uk.

Abstract

BACKGROUND:

The long-term effect of viral infections on graft dysfunction and rejection after renal transplantation is uncertain.

METHODS:

A cohort of 37 renal transplant recipients was followed prospectively for 3 years. Creatinine clearance rate at 6 months and 3 years and chronic allograft nephropathy were correlated with the detection of cytomegalovirus (CMV), human herpesvirus 6 and human herpesvirus 7 and BK virus DNA, CMV disease, and acute rejection.

RESULTS:

CMV disease was significantly associated with poor graft function at 6 months, whereas chronic allograft nephropathy was associated with graft dysfunction at 3 years. Both CMV disease and detection of human herpesvirus 6 DNA were associated with chronic allograft nephropathy.

CONCLUSIONS:

CMV disease was a significant cause of early graft dysfunction, whereas the presence of chronic allograft nephropathy was the main determinant of poor long-term graft function. The role of viral infections in chronic allograft nephropathy deserves further investigation.

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